Random Dense Packing Parameters of Two-Dimensional Spherical Powders for Hot Isostatic Pressing Process Modeling

In this paper, we have used the hot isostatic pressing HIP models previously carried out for the study of the random dense packing densification (RDP) of spherical particles of the same size in order to adapt them to the RDP of two-dimensional spherical particles. A new microscopic approach is thus developed that allows the densification parameters of two-dimensional spherical powder aggregates to be evaluated as a function of the relative density, taking into account the morphological changes of the powder particles and the porosity. The equations obtained for each parameter (coordination number, mean contact area and effective pressure) made it possible to represent the results in the form of curves. These show that our new approach is well adapted to a realistic description of the densification of powder aggregates with particles of more or less similar sizes.

Random Dense Packing Parameters of Two-Dimensional Spherical Powders for Hot Isostatic Pressing Process Modeling

In this paper, we have used the hot isostatic pressing HIP models previously carried out for the study of the random dense packing densification (RDP) of spherical particles of the same size in order to adapt them to the RDP of two-dimensional spherical particles. A new microscopic approach is thus developed that allows the densification parameters of two-dimensional spherical powder aggregates to be evaluated as a function of the relative density, taking into account the morphological changes of the powder particles and the porosity. The equations obtained for each parameter (coordination number, mean contact area and effective pressure) made it possible to represent the results in the form of curves. These show that our new approach is well adapted to a realistic description of the densification of powder aggregates with particles of more or less similar sizes.

Comparative Analysisof Ontology Alignment Methodology

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Compensatory Adaptive Neural Fuzzy Inference System

The traditional approach to fuzzy design is based on knowledge acquired by expert operators formulated into rules. However, operators may not be able to translate their knowledge and experience into a fuzzy logic controller. In addition, most adaptive fuzzy controllers present difficulties in determining appropriate fuzzy rules and appropriate membership functions. This chapter presents adaptive neural-fuzzy controller equipped with compensatory fuzzy control in order to adjust membership functions, and as well to optimize the adaptive reasoning by using a compensatory learning algorithm. An analysis of stability and transparency based on a passivity framework is carried out. The resulting controllers are implemented on a two degree of freedom robotic system. The simulation results obtained show a fairly high accuracy in terms of position and velocity tracking, what highlights the effectiveness of the proposed controllers

Random Dense Packing Parameters of Two-Dimensional Spherical Powders for Hot Isostatic Pressing Process Modeling

In this paper, we have used the hot isostatic pressing HIP models previously carried out for the study of the random dense packing densification (RDP) of spherical particles of the same size in order to adapt them to the RDP of two-dimensional spherical particles. A new microscopic approach is thus developed that allows the densification parameters of two-dimensional spherical powder aggregates to be evaluated as a function of the relative density, taking into account the morphological changes of the powder particles and the porosity. The equations obtained for each parameter (coordination number, mean contact area and effective pressure) made it possible to represent the results in the form of curves. These show that our new approach is well adapted to a realistic description of the densification of powder aggregates with particles of more or less similar sizes

Structural characterization of antibody drug conjugate by a combination of intact, middle-up and bottom-up techniques using sheathless capillary electrophoresis – Tandem mass spectrometry as nanoESI infusion platform and separation method

Antibody-drug conjugates (ADCs) represent a fast growing class of biotherapeutic products. Their production leads to a distribution of species exhibiting different number of conjugated drugs overlaying the inherent com-plexity resulting from the monoclonal antibody format, such as glycoforms. ADCs require an additional level of characterization compared to first generation of biotherapeutics obtained through multiple analytical tech-niques for complete structure assessment. We report the development of complementary approaches imple-menting sheathless capillary electrophoresis-mass spectrometry (sheathless CE-MS) to characterize the differ-ent aspects defining the structure of brentuximab vedotin. Native MS using sheathless CE-MS instrument as a nanoESI infusion platform enabled accurate mass measurements and estimation of the average drug to anti-body ratio alongside to drug load distribution. Middle-up analysis performed after limited IdeS proteolysis allowed to study independently the light chain, Fab and F(ab’)2 subunits incorporating 1, 0 to 4 and 0 to 8 pay-loads respectively. Finally, a CZE-ESI-MS/MS methodology was developed in order to be compatible with hy-drophobic drug composing ADCs. From a single injection, complete sequence coverage could be achieved. Using the same dataset, glycosylation and drug-loaded peptides could be simultaneously identified revealing robust information regarding their respective localization and abundance. Drug-loaded peptide fragmentation mass spectra study demonstrated drug specific fragments reinforcing identification confidence, undescribed so far. Results reveal the method ability to characterize ADCs primary structure in a comprehensive manner while reducing tremendously the number of experiments required. Data generated showed that sheathless CZE-ESI-MS/MS characteristics position the methodology developed as a relevant alternative for comprehensive multi-level characterization of these complex biomolecule

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

An approach to achieve IT agility by combining SOA with ITSM

Today, service-orientation is considered as a compelling technique for developing agile software systems that best align with business. It is also considered as an important approach for information technology (IT) service management, especially for service delivery and support. However, there is still some confusions and misunderstanding between people as sometimes they are referring to information technology service management (ITSM) services and sometimes to service-oriented architecture (SOA) services. So, the combination of both SOA and ITSM approaches arises. This paper deals with this combination and it provides some principles, policies and models that guide and explain the connections that may exist between the two worlds. Specifically, it provides a service model and governance, which cover the multitude necessary activities for specifying and managing how services are defined and supported within large enterprise

GENESIS OF GYPSUM IN SOILS OF EL OUTAYA PLAIN

Le gypse est le minéral le plus abondant dans les sols des régions arides, il se forme lorsque la concentration de Ca+2 et SO4-2   est élevée dans le sol. Trois profils représentatifs dans la plaine d’El outaya (nord-ouest de Biskra) ont été étudiés. Le climat de la région est aride avec des températures annuelles maximales de 41°C et des précipitations moyennes annuelles de 129.5mm. Les résultats obtenus par l’observation microscopique indiquent que la forme lenticulaire du gypse est la plus abondante dans les différents horizons  des profils étudiés ; tandis qu’il y a d’autres formes rares surtout dans les horizons souterraines, tel que la forme aciculaire .La formation du gypse est fréquent dans les piedmonts (profil 23) et la partie basse de la plaine( Sebkha de Selga)(profil 102 et 103) ,elle est liée à la position topographique, à la formation géologique(Trias) et l’aridité du climat . L'étude de la diffraction par les rayons X a montré  l’abondance du bassanite dans le cortège minéralogique des sols étudiés qui se traduit par la présence des processus de déshydratation